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The peptide is constructed on a GIP receptor backbone with non-coded amino acid residues (Aib2, Aib20, aMeL13) and a C20 fatty diacid moiety that enables albumin binding, extending pharmacokinetic half-life for once-weekly administration in research settings

Clinical research suggested doses in the range of 1-10mcg per kilogram of body weight showed efficacy, though most protocols standardized around 4-6mcg/kg for practical application

In RA, HIF-1 induces the upregulation of receptor activator of NF-B ligand (RANKL) in OBs, ultimately facilitating OCs-mediated bone resorption (137, 139)